Circulating serpin tumor markers SCCA1 and SCCA2 are not actively secreted but reside in the cytosol of squamous carcinoma cells.

@article{Uemura2000CirculatingST,
  title={Circulating serpin tumor markers SCCA1 and SCCA2 are not actively secreted but reside in the cytosol of squamous carcinoma cells.},
  author={Yoshiki Uemura and Stephen C. Pak and Claire Luke and Sule Umit Cataltepe and Christopher Tsu and Colleen Schick and Yoshiro Kamachi and Scott L. Pomeroy and David H. Perlmutter and Richard M. Silverman},
  journal={International journal of cancer},
  year={2000},
  volume={89 4},
  pages={
          368-77
        }
}
An elevation in the circulating level of the squamous-cell carcinoma antigen (SCCA) can be a poor prognostic indicator in certain types of squamous-cell cancers. Total SCCA in the circulation comprises 2 nearly identical, approximately 45 kDa proteins, SCCA1 and SCCA2. Both proteins are members of the high-molecular weight serine proteinase inhibitor (serpin) family with SCCA1 paradoxically inhibiting lysosomal cysteine proteinases and SCCA2 inhibiting chymotrypsin-like serine proteinases… CONTINUE READING
BETA

Citations

Publications citing this paper.
SHOWING 1-10 OF 25 CITATIONS

Similar Papers

Loading similar papers…