Circulating sICAM-1 and sE-Selectin as biomarker of infection and prognosis in patients with systemic inflammatory response syndrome.

@article{Pablo2013CirculatingSA,
  title={Circulating sICAM-1 and sE-Selectin as biomarker of infection and prognosis in patients with systemic inflammatory response syndrome.},
  author={Ra{\'u}l de Pablo and Jorge Monserrat and Eduardo Reyes and David Diaz and Manuel Rodr{\'i}guez-Zapata and Antonio de la Hera and Alfredo Prieto and Melchor {\'A}lvarez-Mon},
  journal={European journal of internal medicine},
  year={2013},
  volume={24 2},
  pages={
          132-8
        }
}
BACKGROUND Vascular endothelium activation is a key pathogenic step in systemic inflammatory response syndrome (SIRS) that can be triggered by both microbial and sterile proinflammatory stimuli. The relevance of soluble adhesion molecules as clinical biomarkers to discriminate between infectious and non-infectious SIRS, and the individual patient prognosis, has not been established. METHODS We prospectively measured by sandwich ELISA, serum levels of soluble E-Selectin (sE-Selectin), soluble… CONTINUE READING
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