Circulating resistin in lean, obese, and insulin-resistant mouse models: lack of association with insulinemia and glycemia.

  title={Circulating resistin in lean, obese, and insulin-resistant mouse models: lack of association with insulinemia and glycemia.},
  author={Jennifer Lee and John W. Bullen and Violeta Stoyneva and Christos S. Mantzoros},
  journal={American journal of physiology. Endocrinology and metabolism},
  volume={288 3},
Resistin is an adipocyte-secreted hormone proposed to link obesity with insulin resistance and diabetes, but no previous study has performed a joint quantitative evaluation of white adipose tissue (WAT) resistin mRNA expression and serum levels in relation to insulinemia and glycemia in mice. We have thus comparatively assessed WAT resistin mRNA expression and serum resistin levels in lean C57BL/6J mice and various mouse models of obesity, including diet-induced obese (DIO) C57BL/6J mice, high… 

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