Circulating progenitor epithelial cells traffic via CXCR4/CXCL12 in response to airway injury.

@article{Gomperts2006CirculatingPE,
  title={Circulating progenitor epithelial cells traffic via CXCR4/CXCL12 in response to airway injury.},
  author={Brigitte Gomperts and John A Belperio and P Nagesh Rao and Scott H. Randell and Michael C. Fishbein and Marie D. Burdick and Robert M. Strieter},
  journal={Journal of immunology},
  year={2006},
  volume={176 3},
  pages={1916-27}
}
Recipient airway epithelial cells are found in human sex-mismatched lung transplants, implying that circulating progenitor epithelial cells contribute to the repair of the airway epithelium. Markers of circulating progenitor epithelial cells and mechanisms for their trafficking remain to be elucidated. We demonstrate that a population of progenitor epithelial cells exists in the bone marrow and the circulation of mice that is positive for the early epithelial marker cytokeratin 5 (CK5) and the… CONTINUE READING

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