Circulating prediagnostic interleukin-6 and C-reactive protein and prostate cancer incidence and mortality.

@article{Stark2009CirculatingPI,
  title={Circulating prediagnostic interleukin-6 and C-reactive protein and prostate cancer incidence and mortality.},
  author={Jennifer Rider Stark and Haojie Li and Peter Kraft and Tobias Kurth and Edward L. Giovannucci and Meir Jonathan Stampfer and Jing Ma and Lorelei A. Mucci},
  journal={International journal of cancer},
  year={2009},
  volume={124 11},
  pages={2683-9}
}
Interleukin-6 (IL-6) and C-reactive protein (CRP) are elevated in prostate cancer patients, but the role of prediagnostic levels of these inflammatory mediators on prostate cancer outcomes is unclear. We undertook a large, prospective case-control study to evaluate the relation between prediagnostic levels of IL-6 and CRP and prostate cancer incidence and mortality. We also investigated the role of the IL-6 (-174 G/C) polymorphism in relation to circulating levels of IL-6 and CRP, as well as… CONTINUE READING