Circulating platelet-activating factor is primarily cleared by transport, not intravascular hydrolysis by lipoprotein-associated phospholipase A2/ PAF acetylhydrolase.

@article{Liu2011CirculatingPF,
  title={Circulating platelet-activating factor is primarily cleared by transport, not intravascular hydrolysis by lipoprotein-associated phospholipase A2/ PAF acetylhydrolase.},
  author={Jinbo Liu and Rui Chen and Gopal Kedihitlu Marathe and Maria Febbraio and Weilin Zou and Thomas M McIntyre},
  journal={Circulation research},
  year={2011},
  volume={108 4},
  pages={469-77}
}
RATIONALE The phospholipid platelet-activating factor (PAF) stimulates all cells of the innate immune system and numerous cardiovascular cells. A single enzyme (plasma PAF acetylhydrolase [PAF-AH] or lipoprotein-associated phospholipase [Lp-PL]A(2)) in plasma hydrolyzes PAF, but significant controversy exists whether its action is pro- or antiinflammatory and accordingly whether its inhibition will slow cardiovascular disease. OBJECTIVE We sought to define how PAF and related short-chain… CONTINUE READING
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