Circulating plasma receptors for tumour necrosis factor in Malawian children with severe falciparum malaria.

@article{Molyneux1993CirculatingPR,
  title={Circulating plasma receptors for tumour necrosis factor in Malawian children with severe falciparum malaria.},
  author={Malcolm Edward Molyneux and Hartmut Engelmann and Terrie E. Taylor and Jack J Wirima and Dan Aderka and David Wallach and Georges Emile Raymond Grau},
  journal={Cytokine},
  year={1993},
  volume={5 6},
  pages={604-9}
}
Tumour necrosis factor (TNF) concentrations are increased in the plasma during a malarial illness, and are highest in patients with severe or fatal disease. We have studied the plasma concentrations of two soluble receptors (sTNF-R1 and sTNF-R2), which act as binding proteins for TNF, in children with falciparum malaria. In 52 Malawian children with malaria, plasma concentrations of both sTNF-R1 (mean (S.D.) 4759(2552) pg/ml) and sTNF-R2 (59077(37102) pg/ml) were greatly increased when compared… CONTINUE READING

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