Circulating plasma platelet activating factor in persistent pulmonary hypertension of the newborn.

@article{Caplan1990CirculatingPP,
  title={Circulating plasma platelet activating factor in persistent pulmonary hypertension of the newborn.},
  author={Michael S. Caplan and Willa A. Hsueh and Xio Ming Sun and Samuel S. Gidding and Joseph R. Hageman},
  journal={The American review of respiratory disease},
  year={1990},
  volume={142 6 Pt 1},
  pages={1258-62}
}
Platelet activating factor (PAF) is an endogenous phospholipid mediator that causes pulmonary hypertension and thrombocytopenia in experimental animal models. To investigate circulating PAF in persistent pulmonary hypertension of the newborn (PPHN), we studied PAF and its degradative enzyme, acetylhydrolase. Thirteen neonates with PPHN, diagnosed by routine clinical methods including echocardiography, were compared to six age-matched control patients with respiratory distress. Overall, plasma… CONTINUE READING

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