Circulating phthalates during critical illness in children are associated with long-term attention deficit: a study of a development and a validation cohort

@article{Verstraete2015CirculatingPD,
  title={Circulating phthalates during critical illness in children are associated with long-term attention deficit: a study of a development and a validation cohort},
  author={S{\"o}ren Verstraete and Ilse Vanhorebeek and Aurelia Covaci and Fabi{\'a}n G{\"u}iza and Govindan Malarvannan and Philippe Jorens and Greet Van den Berghe},
  journal={Intensive Care Medicine},
  year={2015},
  volume={42},
  pages={379-392}
}
Environmental phthalate exposure has been associated with attention deficit disorders in children. We hypothesized that in children treated in the pediatric intensive care unit (PICU), circulating phthalates leaching from indwelling medical devices contribute to their long-term attention deficit. Circulating plasma concentrations of di(2-ethylhexyl)phthalate (DEHP) metabolites were quantified in 100 healthy children and 449 children who had been treated in PICU and were neurocognitively tested… CONTINUE READING

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