Circulating nucleated peripheral blood cells contribute to early-phase meniscal healing.

@article{Yamasaki2017CirculatingNP,
  title={Circulating nucleated peripheral blood cells contribute to early-phase meniscal healing.},
  author={Shinya Yamasaki and Yusuke Hashimoto and Junsei Takigami and Shozaburo Terai and Masafumi Takahashi and Shigeyuki Wakitani and Hiroaki Nakamura},
  journal={Journal of tissue engineering and regenerative medicine},
  year={2017},
  volume={11 3},
  pages={609-617}
}
The purpose of this study was to assess how peripheral blood cells (PBCs) contribute to meniscus repair, using a parabiotic rat model. Wild-type (WT) and green fluorescent protein (GFP) transgenic rats were conjoined at the torso. After 4 weeks, the anterior part of the medial meniscus of both groups of rats was removed. At 1, 2, 4, 8 and 12 weeks post-meniscectomy, repaired tissue was evaluated using stereomicroscopy, histology with toluidine blue staining, and immunofluorescence microscopy… CONTINUE READING