Circulating nociceptin levels during the cluster headache period.

  title={Circulating nociceptin levels during the cluster headache period.},
  author={Csaba Ertsey and M{\'o}nika Beatrix Hantos and Gy{\"o}rgy Bozsik and Korn{\'e}lia Tekes},
  journal={Cephalalgia : an international journal of headache},
  volume={24 4},
The trigeminal innervation of the dura and its vessels has a prominent role in the mechanism of cluster headache. Nociceptin, an opioid neuropeptide, is the endogenous ligand of the OP-4 receptor, with both algesic and analgesic properties depending on the site of action. Nociceptin and its receptor are expressed by trigeminal ganglion cells where they co-localize with calcitonin gene-related peptide, a marker peptide of the trigeminovascular neurones. Nociceptin inhibits neurogenic dural… CONTINUE READING

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