Circulating nitrite/nitrate levels increase with follicular development: indirect evidence for estradiol mediated NO release.

@article{Rosselli1994CirculatingNL,
  title={Circulating nitrite/nitrate levels increase with follicular development: indirect evidence for estradiol mediated NO release.},
  author={Marinella Rosselli and B Imthurm and Ervin Ma{\'c}as and Paul J. Keller and Raghvendra K Dubey},
  journal={Biochemical and biophysical research communications},
  year={1994},
  volume={202 3},
  pages={
          1543-52
        }
}
Ovarian dysfunction as well as impaired release of endothelium-derived nitric oxide (NO) is associated with increased incidence of cardiovascular disease in postmenopausal women. Estrogen replacement therapy in postmenopausal women has a cardioprotective effect. Hence, using follicular development (FD) phase of the menstrual cycle of normal women (n = 7) and of patients undergoing in vitro fertilization (n = 16), we tested whether ovarian/sex hormones modulate NO-release. Levels of nitrite… CONTINUE READING
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