Circulating myeloid dendritic cells of advanced cancer patients result in reduced activation and a biased cytokine profile in invariant NKT cells.

@article{Vliet2008CirculatingMD,
  title={Circulating myeloid dendritic cells of advanced cancer patients result in reduced activation and a biased cytokine profile in invariant NKT cells.},
  author={Hans J. J. van der Vliet and Ruojie Wang and Simon C. Yue and Henry B. Koon and Steven P. Balk and Mark Adrian Exley},
  journal={Journal of immunology},
  year={2008},
  volume={180 11},
  pages={7287-93}
}
CD1d-restricted invariant NKT (iNKT) cells play important regulatory roles in various immune responses, including antitumor immune responses. Previous studies have demonstrated quantitative and qualitative defects in iNKT cells of cancer patients, and these defects are clinically relevant as they are associated with poor prognosis. In this study we demonstrate that defects in the iNKT cell population can, at least in part, be attributed to defective interactions between iNKT cells and CD1d… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 19 extracted citations

Adoptive Transfer of Invariant NKT Cells as Immunotherapy for Advanced Melanoma: A Phase I Clinical Trial.

Clinical cancer research : an official journal of the American Association for Cancer Research • 2017
View 3 Excerpts

Similar Papers

Loading similar papers…