Circulating monocytes are not a major reservoir of HIV-1 in elite suppressors.

  title={Circulating monocytes are not a major reservoir of HIV-1 in elite suppressors.},
  author={Adam M Spivak and Maria A. S. Salgado and S. Alireza Rabi and Karen A O'Connell and Joel N Blankson},
  journal={Journal of virology},
  volume={85 19},
Circulating HIV-1-infected monocytes have been identified in patients on highly active antiretroviral therapy and may represent an important barrier to viral eradication. The nature of these cells in HIV-1-infected patients who maintain undetectable viral loads and preserved CD4(+) T cell counts without antiretroviral therapy (known as elite controllers or elite suppressors [ES]) is unknown. We describe here infrequent recovery of proviral HIV-1 DNA from circulating monocytes relative to CD4… CONTINUE READING

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