Circulating microparticles remain associated with complement activation despite intensive anti-inflammatory therapy in early rheumatoid arthritis.

@article{Eijk2010CirculatingMR,
  title={Circulating microparticles remain associated with complement activation despite intensive anti-inflammatory therapy in early rheumatoid arthritis.},
  author={Izhar C. van Eijk and Maarten E. Tushuizen and Augueste Sturk and Ben A. C. Dijkmans and Maarten Boers and Alexandre E. Voskuyl and Michaela Diamant and Gerrit Jan J Wolbink and Rienk Nieuwland and Michael T. Nurmohamed},
  journal={Annals of the rheumatic diseases},
  year={2010},
  volume={69 7},
  pages={1378-82}
}
OBJECTIVES Rheumatoid arthritis (RA) is a chronic systemic inflammatory disease characterised by synovitis and joint destruction. The pathogenesis of RA is not clear, but is considered to be an immune-mediated inflammatory disorder, in which the complement system plays an important role. Although cell-derived microparticles (MPs) have been associated with… CONTINUE READING