Circulating microparticles reflect treatment effects and clinical status in multiple sclerosis.

@article{SenzCuesta2014CirculatingMR,
  title={Circulating microparticles reflect treatment effects and clinical status in multiple sclerosis.},
  author={Mat{\'i}as S{\'a}enz-Cuesta and Haritz Irizar and Tamara Castillo-Trivi{\~n}o and Maider Mu{\~n}oz-Culla and I Osorio-Querejeta and Alvaro Prada and Luc{\'i}a Prensa Sep{\'u}lveda and Mar{\'i}a Paz L{\'o}pez-Mato and Adolfo L{\'o}pez de Mun{\'a}in and Manuel Comabella and Luisa M Villar and Javier Olascoaga and David Otaegui},
  journal={Biomarkers in medicine},
  year={2014},
  volume={8 5},
  pages={653-61}
}
AIM To evaluate whether circulating microparticles (MPs) derived from three cell subtypes (platelets, total leukocytes or monocytes) obtained from multiple sclerosis (MS) patients were modulated depending on the clinical status and to investigate the effect of treatments on MP levels. PATIENTS & METHODS The MP counts were assessed with flow cytometry. RESULTS The platelet-derived MP level was higher in untreated MS patients than controls. Relapsing-remitting patients showed the highest… CONTINUE READING

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