Circulating microparticles from patients with myocardial infarction cause endothelial dysfunction.

@article{Boulanger2001CirculatingMF,
  title={Circulating microparticles from patients with myocardial infarction cause endothelial dysfunction.},
  author={Chantal M Boulanger and A Scoazec and Talin Ebrahimian and P. G. Henry and Eric Mathieu and Alain Tedgui and Ziad Mallat},
  journal={Circulation},
  year={2001},
  volume={104 22},
  pages={2649-52}
}
BACKGROUND Shed membrane microparticles circulate in the peripheral blood of nonischemic (NI) patients and patients with myocardial infarction (MI). We investigated whether or not these microparticles would affect endothelium-dependent responses. METHODS AND RESULTS Rat aortic rings with endothelium were exposed for 24 hours to circulating microparticles isolated from 7 patients with NI syndromes and 19 patients with acute MI. Endothelium-dependent relaxations to acetylcholine were not… CONTINUE READING
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