Circulating microparticles carry oxidation-specific epitopes and are recognized by natural IgM antibodies1[S]

@inproceedings{Tsiantoulas2015CirculatingMC,
  title={Circulating microparticles carry oxidation-specific epitopes and are recognized by natural IgM antibodies1[S]},
  author={Dimitrios Tsiantoulas and Thomas Perkmann and Taras Afonyushkin and Andreas Mangold and Thomas A. Prohaska and Nikolina Papac-Milicevic and Vincent Millischer and Caroline Bartel and Sohvi H{\"o}rkk{\"o} and Chantal M. Boulanger and Sotirios Tsimikas and Michael Bernhard Fischer and Joseph L. Witztum and Irene M Lang and Christoph J. Binder},
  booktitle={Journal of lipid research},
  year={2015}
}
Oxidation-specific epitopes (OSEs) present on apoptotic cells and oxidized low density lipoprotein (OxLDL) represent danger-associated molecular patterns that are recognized by different arcs of innate immunity, including natural IgM antibodies. Here, we investigated whether circulating microparticles (MPs), which are small membrane vesicles released by apoptotic or activated cells, are physiological carriers of OSEs. OSEs on circulating MPs isolated from healthy donors and patients with ST… CONTINUE READING
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