Circulating microparticles: pathophysiology and clinical implications.

  title={Circulating microparticles: pathophysiology and clinical implications.},
  author={Andrea Piccin and William G. Murphy and Owen Patrick Smith},
  journal={Blood reviews},
  volume={21 3},
Microparticles (MP) derived from vascular endothelium or circulating blood cells circulate in the peripheral blood. They originate from blebbing and shedding from cell membrane surfaces in physiological and pathological conditions and are present in low concentrations in normal plasma. Increased levels are generated by a number of mechanisms including platelet activation, direct vascular endothelial damage, thrombin activity on the cell surface, C5b-9 activation, and PF4-heparin-antibody… CONTINUE READING
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