Circulating microRNA biomarker studies: pitfalls and potential solutions.

  title={Circulating microRNA biomarker studies: pitfalls and potential solutions.},
  author={Kenneth W. Witwer},
  journal={Clinical chemistry},
  volume={61 1},
BACKGROUND Circulating microRNAs have been proposed as disease biomarkers that may aid in risk assessment, diagnosis, prognosis, and monitoring of treatment response. The perceived opportunity has loomed particularly large in neoplastic disease, where alterations in cancer cells are thought to be reflected in the extracellular space as affected cells release upregulated miRNAs or fail to release apparently downregulated species. Despite the promise of miRNA biomarkers, evaluation of the… CONTINUE READING
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