Circulating miRNAs as surrogate markers for circulating tumor cells and prognostic markers in metastatic breast cancer.

@article{Madhavan2012CirculatingMA,
  title={Circulating miRNAs as surrogate markers for circulating tumor cells and prognostic markers in metastatic breast cancer.},
  author={Dharanija Madhavan and Manuela Zucknick and Markus Wallwiener and Katarina {\'C}uk and Caroline Modugno and Martina Scharpff and Sarah Schott and Joerg Heil and Andrey A Turchinovich and Rongxi Yang and Axel Benner and Sabine Riethdorf and Andreas Trumpp and Christof Sohn and Klaus Pantel and Andreas Schneeweiss and Barbara Burwinkel},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  year={2012},
  volume={18 21},
  pages={5972-82}
}
PURPOSE The use of circulating tumor cells (CTC) as a prognostic marker in metastatic breast cancer (MBC) has been well established. However, their efficacy and accuracy are still under scrutiny mainly because of methods of their enrichment and identification. We hypothesized that circulating miRNAs can predict the CTC status of patients with MBC, and tested for the same. Furthermore, we aimed at establishing a panel of circulating miRNAs capable of differentiating MBC cases from healthy… CONTINUE READING