Circulating miRNAs and miRNA shuttles as biomarkers: Perspective trajectories of healthy and unhealthy aging.

@article{Olivieri2017CirculatingMA,
  title={Circulating miRNAs and miRNA shuttles as biomarkers: Perspective trajectories of healthy and unhealthy aging.},
  author={Fabiola Olivieri and Miriam Capri and Massimiliano Bonaf{\'e} and Cristina Morsiani and Hwa Jin Jung and Liana Spazzafumo and J. Vi{\~n}a and Yousin Suh},
  journal={Mechanisms of ageing and development},
  year={2017},
  volume={165 Pt B},
  pages={
          162-170
        }
}
Human aging is a lifelong process characterized by a continuous trade-off between pro-and anti-inflammatory responses, where the best-adapted and/or remodeled genetic/epigenetic profile may develop a longevity phenotype. Centenarians and their offspring represent such a phenotype and their comparison to patients with age-related diseases (ARDs) is expected to maximize the chance to unravel the genetic makeup that better associates with healthy aging trajectories. Seemingly, such comparison is… CONTINUE READING
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