Circulating miR-378 in plasma: a reliable, haemolysis-independent biomarker for colorectal cancer

  title={Circulating miR-378 in plasma: a reliable, haemolysis-independent biomarker for colorectal cancer},
  author={Susanna Zanutto and Sara Pizzamiglio and Marco Ghilotti and Claudia Bertan and Fernando Ravagnani and Francesco Perrone and Ermanno Leo and Silvana Pilotti and Paolo Verderio and Manuela Gariboldi and Marco Alessandro Pierotti},
  booktitle={British Journal of Cancer},
Background:Plasma circulating tumour-specific microRNAs (miRNAs) are promising biomarkers of tumour presence and recurrence, especially for diseases whose best chance of successful treatment requires early diagnosis and timely surgery of an already malignant but not yet invasive tumour, such as colorectal cancer (CRC).Methods:Expression levels of miRNAs previously found to be differently expressed in tumour vs normal colon tissues were investigated by quantitative real-time PCR in plasma from… CONTINUE READING


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