Circulating miR-378 and miR-451 in serum are potential biomarkers for renal cell carcinoma

  title={Circulating miR-378 and miR-451 in serum are potential biomarkers for renal cell carcinoma},
  author={Martina Redova and Alexandr Poprach and Jana Nekvindov{\'a} and Robert Iliev and Lenka Radov{\'a} and Radek Lakomỳ and Marek Svoboda and Rostislav Vyzula and Ondrej Slaby},
  booktitle={Journal of Translational Medicine},
There is no standard serum biomarker used for diagnosis or early detection of recurrence for renal cell carcinoma (RCC) patients. MicroRNAs (miRNAs) are abundant and highly stable in blood serum, and have been recently described as powerful circulating biomarkers in a wide range of solid cancers. Our aim was to identify miRNA signature that can distinguish the blood serum of RCC patients and matched healthy controls and validate identified miRNAs as potential biomarkers for RCC. In the… CONTINUE READING
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Figure 3 ROC curve for combination of serum miR-378 and miR-451 yielded AUC of 0.86, the sensitivity of 81% and specificity of 83% in discriminating RCC

  • CH Lawrie, S Gal, +9 authors AL Harris
  • Redova et al. Journal of Translational Medicine
  • 2012
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