Circulating miR-34a levels correlate with age-related hearing loss in mice and humans.

@article{Pang2016CirculatingML,
  title={Circulating miR-34a levels correlate with age-related hearing loss in mice and humans.},
  author={Jiaqi Pang and Hao Xiong and Haidi Yang and Yongkang Ou and Yaodong Xu and Qiuhong Huang and Lan Lai and Suijun Chen and Zhigang Zhang and Yuexin Cai and Yiqing Zheng},
  journal={Experimental gerontology},
  year={2016},
  volume={76},
  pages={58-67}
}
Age-related hearing loss (AHL) is a progressive neurodegenerative disease that is largely silent in its initial stages. There is no sensitive blood biomarker for diagnosis or early detection of AHL. MicroRNAs (miRNAs or miRs) are abundant and highly stable in blood, and have been recently described as powerful circulating biomarkers in a wide range of diseases. In the present study, we identified concordant increases in miR-34a levels in the cochlea, auditory cortex, and plasma of C57BL/6 mice… CONTINUE READING