Corpus ID: 12307376

Circulating miR-18a: a sensitive cancer screening biomarker in human cancer.

@article{Komatsu2014CirculatingMA,
  title={Circulating miR-18a: a sensitive cancer screening biomarker in human cancer.},
  author={S. Komatsu and D. Ichikawa and H. Takeshita and R. Morimura and S. Hirajima and M. Tsujiura and T. Kawaguchi and M. Miyamae and H. Nagata and H. Konishi and A. Shiozaki and E. Otsuji},
  journal={In vivo},
  year={2014},
  volume={28 3},
  pages={
          293-7
        }
}
MicroRNAs have been reported to be stably detectable in plasma/serum and to exhibit resistance to endogenous ribonuclease activity because of binding to proteins such as Argonaute-2 and high-density lipoprotein, or being packed by secretory particles such as exosomes. These secretory particles include specific microRNAs and can function as intercellular transmitters. These findings could open-up a new and promising field in the use of circulating microRNAs for cancer treatment. In particular… Expand
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