Circulating miR-182 is a biomarker of colorectal adenocarcinoma progression

  title={Circulating miR-182 is a biomarker of colorectal adenocarcinoma progression},
  author={Lisa Perilli and Caterina Vicentini and Marco Agostini and Silvia Pizzini and Marco Pizzi and Edoardo D'Angelo and Stefania Bortoluzzi and Susanna Mandruzzato and Enzo Mammano and M Rugge and Donato Nitti and Aldo Scarpa and Matteo Fassan and Paola Zanovello},
MiR-182 expression was evaluated by qRT-PCR and in situ hybridization in 20 tubular adenomas, 50 colorectal carcinoma (CRC), and 40 CRC liver metastases. Control samples obtained from patients with irritable bowel syndrome, or tumor-matched normal colon mucosa were analyzed (n=50). MiR-182 expression increased progressively and significantly along with the colorectal carcinogenesis cascade, and in CRC liver metastases. The inverse relation between miR-182 and the expression of its target gene… CONTINUE READING
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