Circulating miR-17-3p, miR-29a, miR-92a and miR-135b in serum: Evidence against their usage as biomarkers in colorectal cancer.

@article{Faltejskova2012CirculatingMM,
  title={Circulating miR-17-3p, miR-29a, miR-92a and miR-135b in serum: Evidence against their usage as biomarkers in colorectal cancer.},
  author={Petra Faltejskova and Ondrej Bocanek and Milana Sachlova and Marek Svoboda and Igor Kiss and Rostislav Vyzula and Ondrej Slaby},
  journal={Cancer biomarkers : section A of Disease markers},
  year={2012},
  volume={12 4},
  pages={199-204}
}
BACKGROUND Colorectal cancer (CRC) is one of the leading causes of cancer-related death in the world. Therefore, there is a high demand for cost-effective and non-invasive biomarkers that would enable an early detection of asymptomatic and curable disease with high sensitivity and specificity. OBJECTIVE The main objective of this study was to investigate the potential of circulating miRNAs as biomarkers of CRC. METHODS Total RNA enriched for small RNAs was isolated from 100~sera of patients… CONTINUE READING

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