Circulating levels of visfatin/pre-B-cell colony-enhancing factor 1 in relation to genotype, GFR, body composition, and survival in patients with CKD.

@article{Axelsson2007CirculatingLO,
  title={Circulating levels of visfatin/pre-B-cell colony-enhancing factor 1 in relation to genotype, GFR, body composition, and survival in patients with CKD.},
  author={Jonas Axelsson and Anna Witasp and Juan Jes{\'u}s Carrero and Abdul Rashid Qureshi and Mohamed E. Suliman and Olof Heimb{\"u}rger and Peter Barany and Bengt Lindholm and Anders Alvestrand and Martin Schalling and Louise Nordfors and Peter Stenvinkel},
  journal={American journal of kidney diseases : the official journal of the National Kidney Foundation},
  year={2007},
  volume={49 2},
  pages={237-44}
}
BACKGROUND Visfatin, also known as pre-B-cell colony-enhancing factor 1 (PBEF-1), recently was shown to be secreted from adipocytes and have insulin-mimetic properties in mice. Because renal failure per se is associated with both increased levels of circulating peptides and marked insulin resistance, even in the absence of diabetes mellitus, we hypothesized that visfatin could be a factor linking inflammation, kidney disease, and insulin resistance in this patient group. METHODS Altogether… CONTINUE READING

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