Circulating levels of tumour necrosis factor-alpha and its soluble receptors are increased in the blood of patients with amyotrophic lateral sclerosis.

@article{Poloni2000CirculatingLO,
  title={Circulating levels of tumour necrosis factor-alpha and its soluble receptors are increased in the blood of patients with amyotrophic lateral sclerosis.},
  author={Marco Poloni and D. Facchetti and R Mai and Anastasia Micheli and Laura Agnoletti and Gloria Francolini and Gabriele Mora and C. Camana and Letizia Mazzini and Tiziana Bachetti},
  journal={Neuroscience letters},
  year={2000},
  volume={287 3},
  pages={211-4}
}
An immunologic pathogenesis for amyotrophic lateral sclerosis (ALS) has been recently proposed. We tested the whole tumour necrosis factor (TNF) system in the serum of 51 ALS patients at different stages of the disease and 36 healthy controls. Antigenic TNF-alpha and its soluble receptors (sTNF-Rs), measured by ELISA, were significantly higher in ALS patients than in healthy controls. However, biologically active TNF-alpha, corresponding to the sTNF-Rs-unbound trimeric TNFalpha molecule and… CONTINUE READING

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