Circulating levels of sphingosine-1-phosphate are elevated in severe, but not mild psoriasis and are unresponsive to anti-TNF-α treatment

@inproceedings{Checa2015CirculatingLO,
  title={Circulating levels of sphingosine-1-phosphate are elevated in severe, but not mild psoriasis and are unresponsive to anti-TNF-α treatment},
  author={Antonio Checa and Ning Xu and Daniel Garc{\'i}a Sar and Jesper Z. Haeggstr{\"o}m and Mona St{\aa}hle and Craig E. Wheelock},
  booktitle={Scientific reports},
  year={2015}
}
Sphingolipids are bioactive molecules with a putative role in inflammation. Alterations in sphingolipids, in particular ceramides, have been consistently observed in psoriatic skin. Herein, we quantified the circulating sphingolipid profile in individuals with mild or severe psoriasis as well as healthy controls. In addition, the effects of anti-TNF-α treatment were determined. Levels of sphingoid bases, including sphingosine-1-phosphate (S1P), increased in severe (P < 0.001; n = 32), but not… CONTINUE READING
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