Circulating levels of nitric oxide and vascular endothelial growth factor throughout ovine pregnancy.

@article{Vonnahme2005CirculatingLO,
  title={Circulating levels of nitric oxide and vascular endothelial growth factor throughout ovine pregnancy.},
  author={Kimberly A. Vonnahme and Matthew W. Wilson and Yun Li and Heidi L. Rupnow and Terrance M Phernetton and Stephen P. Ford and Ronald R Magness},
  journal={The Journal of physiology},
  year={2005},
  volume={565 Pt 1},
  pages={101-9}
}
Nitric oxide (NO) production has been shown to increase uterine blood flow and be elevated in ewes carrying multiple fetuses during late gestation. Vascular endothelial growth factor (VEGF) has been reported to increase eNOS expression and NO production in endothelial cell cultures. As angiogenesis and vasodilatation of the uterine and placental vascular beds are important at all stages of pregnancy, it is important to understand how VEGF and NO change throughout gestation in circulation… CONTINUE READING