Circulating levels of matrix metalloproteinases MMP-3 and MMP-1, tissue inhibitor of metalloproteinases 1 (TIMP-1), and MMP-1/TIMP-1 complex in rheumatic disease. Correlation with clinical activity of rheumatoid arthritis versus other surrogate markers.

@article{Keyszer1999CirculatingLO,
  title={Circulating levels of matrix metalloproteinases MMP-3 and MMP-1, tissue inhibitor of metalloproteinases 1 (TIMP-1), and MMP-1/TIMP-1 complex in rheumatic disease. Correlation with clinical activity of rheumatoid arthritis versus other surrogate markers.},
  author={Gernot Keyszer and Irini Lambiri and Remco Nagel and C H Keysser and M. Keysser and E J Gromnica-ihle and Juliane K Franz and Gerd ‐ R{\"u}diger Burmester and Klaus Jung},
  journal={The Journal of rheumatology},
  year={1999},
  volume={26 2},
  pages={251-8}
}
OBJECTIVE To investigate whether plasma levels of matrix metalloproteinases 3 (MMP-3, stromelysin), MMP-1 (collagenase), tissue inhibitor of metalloproteinases 1 (TIMP-1), and MMP1/TIMP-1 complex (MT complex) are specifically elevated in erosive joint diseases compared to nonerosive rheumatic diseases, and to assess how these markers reflect the clinical activity of rheumatoid arthritis (RA) compared to circulating cytokines and markers of connective tissue turnover as well as established… CONTINUE READING