Circulating levels of cytochrome C, gamma-glutamyl transferase, triglycerides and unconjugated bilirubin in overweight/obese patients with non-alcoholic fatty liver disease.

@article{Tarantino2011CirculatingLO,
  title={Circulating levels of cytochrome C, gamma-glutamyl transferase, triglycerides and unconjugated bilirubin in overweight/obese patients with non-alcoholic fatty liver disease.},
  author={Giovanni Tarantino and Annamaria Colao and Domenico Capone and Paolo P Conca and Marianna Tarantino and Ernesto Grimaldi and Domenico Chianese and Carmine Finelli and Federica Contaldo and Francesco Scopacasa and Silvia Savastano},
  journal={Journal of biological regulators and homeostatic agents},
  year={2011},
  volume={25 1},
  pages={47-56}
}
Non-alcoholic fatty liver disease, characterized by hepatocyte apoptosis, is distinct in fatty liver and non-alcoholic steatohepatitis, the more severe form. Apoptotic cell death is caspase-dependent and associated with mitochondrial membrane depolarization and cytochrome c release. Adhering to the hypothesis that the exposure of hepatocytes to free fatty acids, resulting in increased ROS production and mitochondrial damage, is balanced by the presence of antioxidant substances, circulating… CONTINUE READING

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