Circulating levels of IL-6 and TNF-α are associated with knee radiographic osteoarthritis and knee cartilage loss in older adults.

@article{Stannus2010CirculatingLO,
  title={Circulating levels of IL-6 and TNF-α are associated with knee radiographic osteoarthritis and knee cartilage loss in older adults.},
  author={Oliver Patrick Stannus and Graeme Jones and Flavia Cicuttini and Venkateswaran Parameswaran and Steve J Quinn and John Burgess and Changhai Ding},
  journal={Osteoarthritis and cartilage},
  year={2010},
  volume={18 11},
  pages={1441-7}
}
OBJECTIVE The role of inflammation in osteoarthritis (OA) pathogenesis is unclear, and the associations between inflammatory cytokines and cartilage loss have not been reported. We determined the associations between serum levels of interleukin (IL)-6 and tumor necrosis factor-α (TNF-α), knee radiographic OA (ROA) and cartilage loss over 2.9 years in older adults. METHODS A total of 172 randomly selected subjects (mean 63 years, range 52-78, 47% female) were studied at baseline and… CONTINUE READING

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