Circulating levels of IGF-1 directly regulate bone growth and density.

@article{Yakar2002CirculatingLO,
  title={Circulating levels of IGF-1 directly regulate bone growth and density.},
  author={Shoshana Yakar and Clifford J. Rosen and Wesley G. Beamer and Cheryl L. Ackert-Bicknell and Yiping Wu and Jun-li Liu and Guck T Ooi and Jennifer Setser and Jan Frystyk and Yves R. Boisclair and Derek Leroith},
  journal={The Journal of clinical investigation},
  year={2002},
  volume={110 6},
  pages={
          771-81
        }
}
IGF-1 is a growth-promoting polypeptide that is essential for normal growth and development. In serum, the majority of the IGFs exist in a 150-kDa complex including the IGF molecule, IGF binding protein 3 (IGFBP-3), and the acid labile subunit (ALS). This complex prolongs the half-life of serum IGFs and facilitates their endocrine actions. Liver IGF-1-deficient (LID) mice and ALS knockout (ALSKO) mice exhibited relatively normal growth and development, despite having 75% and 65% reductions in… CONTINUE READING
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References

Publications referenced by this paper.
Showing 1-10 of 33 references

Normal growth and development in the absence of hepatic insulin-like growth factor I.

Proceedings of the National Academy of Sciences of the United States of America • 1999
View 7 Excerpts
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Clinical review 123: Anabolic therapy for osteoporosis.

The Journal of clinical endocrinology and metabolism • 2001

Postnatal and pubertal skeletal changes contribute predominantly to the differences in peak bone density between C3H/HeJ and C57BL/6J mice.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research • 2001
View 1 Excerpt

Inactivation of the acid labile subunit gene in mice results in mild retardation of postnatal growth despite profound disruptions in the circulating insulin - like growth factor sys

S. Yakar
Proc . Natl . Acad . Sci . USA . • 2000

Inactivation of the acid labile subunit gene in mice results in mild retardation of postnatal growth despite profound disruptions in the circulating insulin-like growth factor system

I Ueki
Proc. Natl. Acad. Sci. USA • 2000
View 3 Excerpts

Direct three-dimensional morphometric analysis of human cancellous bone: microstructural data from spine, femur, iliac crest, and calcaneus.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research • 1999
View 1 Excerpt