Circulating let-7 levels in plasma and extracellular vesicles correlate with hepatic fibrosis progression in chronic hepatitis C.

@article{Matsuura2016CirculatingLL,
  title={Circulating let-7 levels in plasma and extracellular vesicles correlate with hepatic fibrosis progression in chronic hepatitis C.},
  author={Kentaro Matsuura and Valeria De Giorgi and Cathy A Schechterly and Richard Yuan-Hu Wang and Patrizia Farci and Yasuhito Tanaka and HarveyT. Alter},
  journal={Hepatology},
  year={2016},
  volume={64 3},
  pages={
          732-45
        }
}
UNLABELLED The goal of this study was to determine whether an association exists between circulating microRNA (miRNA) levels and disease progression in chronic hepatitis C (CHC), whether plasma or extracellular vesicles (EVs) were optimal for miRNA measurement and their correlation with hepatic miRNA expression, and the mechanistic plausibility of this association. We studied 130 CHC patients prospectively followed over several decades. A comprehensive miRNA profile in plasma using microarray… CONTINUE READING
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