Circulating leptin levels and weight loss in Alzheimer's disease patients.

  title={Circulating leptin levels and weight loss in Alzheimer's disease patients.},
  author={Dermot A Power and Jerry Noel and Ruth D G Collins and Desmond O'neill},
  journal={Dementia and geriatric cognitive disorders},
  volume={12 2},
Weight loss is common in Alzheimer's disease (AD) and is predictive of mortality. Leptin, an adipocyte-derived peptide hormone is implicated in the regulation of satiety and energy expenditure. It acts on the hypothalamus to suppress appetite and increase energy expenditure. We undertook this study to determine if inappropriately elevated leptin levels play a role in AD-associated weight loss. Serum leptin levels of 8 patients in each of the following groups were determined: (1) AD, body mass… CONTINUE READING


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