Circulating insulin-like growth factor-1 and its binding protein-3: metabolic and genetic correlates in the community.

@article{Lam2010CirculatingIG,
  title={Circulating insulin-like growth factor-1 and its binding protein-3: metabolic and genetic correlates in the community.},
  author={Carolyn S. P. Lam and M C Chen and Sean M Lacey and Qiong Yang and Lisa Sullivan and Vanessa Xanthakis and Radwan Safa and H. Gregory Smith and Xuyang Peng and Douglas Brian Sawyer and Ramachandran S. Vasan},
  journal={Arteriosclerosis, thrombosis, and vascular biology},
  year={2010},
  volume={30 7},
  pages={1479-84}
}
OBJECTIVE The metabolic and genetic correlates of circulating insulin-like growth factor-1 (IGF-1) and its main circulating carrier, IGF-1-binding-protein-3 (IGFBP-3), are unclear. METHODS AND RESULTS We measured serum IGF-1 and IGFBP-3 concentrations in a sample of the Framingham Heart Study (N=3977, aged 40+/-9 years, 46% male) and evaluated their relations to cardiovascular risk factors using multivariable regression. Serum IGF-1 was inversely correlated with age, body mass index, total… CONTINUE READING
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