Circulating insulin inhibits glucagon secretion induced by arginine in type 1 diabetes.

@article{Oskarsson2000CirculatingII,
  title={Circulating insulin inhibits glucagon secretion induced by arginine in type 1 diabetes.},
  author={Per Oskarsson and P. E. Lins and B Ahr{\'e} and Ulf Adamson},
  journal={European journal of endocrinology},
  year={2000},
  volume={142 1},
  pages={30-4}
}
OBJECTIVE To evaluate if insulin has a suppressive effect on the glucagon secretion stimulated by arginine in type 1 diabetes. RESEARCH DESIGN AND METHODS The alpha-cell response to an i.v. bolus of arginine (150mgkg(-1)) followed by an infusion of arginine (10mgkg(-1)min(-1)) was studied in random order during either low dose infusion (LDT) or high dose infusion (HDT) of insulin in ten patients with type 1 diabetes. The blood glucose level was clamped at an arterialized level of 5mmoll(-1… CONTINUE READING

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