Circulating inflammatory markers are associated with magnetic resonance imaging-visible perivascular spaces but not directly with white matter hyperintensities.

@article{Aribisala2014CirculatingIM,
  title={Circulating inflammatory markers are associated with magnetic resonance imaging-visible perivascular spaces but not directly with white matter hyperintensities.},
  author={Benjamin S. Aribisala and Stewart J Wiseman and Zoe Morris and Maria Valdes-Hernandez and Natalie A. Royle and Susana Mu{\~n}oz Maniega and Alan J. Gow and Janie Corley and Mark E. Bastin and John M. Starr and Ian J. Deary and Joanna M. Wardlaw},
  journal={Stroke},
  year={2014},
  volume={45 2},
  pages={605-7}
}
BACKGROUND AND PURPOSE White matter hyperintensities (WMH) and perivascular spaces (PVS) are features of small vessel disease, found jointly on MRI of older people. Inflammation is a prominent pathological feature of small vessel disease. We examined the association between inflammation, PVS, and WMH in the Lothian Birth Cohort 1936 (N=634). METHODS We measured plasma fibrinogen, C-reactive protein, and interleukin-6 and rated PVS in 3 brain regions. We measured WMH volumetrically and… CONTINUE READING