Circulating immunoreactive endothelin-1 in children with pulmonary hypertension. Association with acute hypoxic pulmonary vasoreactivity.

@article{Allen1993CirculatingIE,
  title={Circulating immunoreactive endothelin-1 in children with pulmonary hypertension. Association with acute hypoxic pulmonary vasoreactivity.},
  author={Steven W. Allen and B A Chatfield and S A Koppenhafer and Michael Schaffer and Robert R. Wolfe and Steven H Abman},
  journal={The American review of respiratory disease},
  year={1993},
  volume={148 2},
  pages={519-22}
}
To determine whether circulating levels of endothelin-1 (ET-1), a potent vasoconstrictor peptide, are elevated in children with pulmonary hypertension and related to the degree of hypoxic pulmonary vasoconstriction, we measured arterial and mixed venous plasma concentrations of immunoreactive ET-1 (irET-1) in 13 children during cardiac catheterization. Clinical diagnoses in seven children with pulmonary hypertension (PH) included chronic lung disease (four children), congenital heart disease… CONTINUE READING
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