Circulating immunoglobulin complexes in Wegener's granulomatosis.

  title={Circulating immunoglobulin complexes in Wegener's granulomatosis.},
  author={Stephen B. Howell and Wallace V. Epstein},
  journal={The American journal of medicine},
  volume={60 2},
Two cases of Wegener's granulomatosis are reported in which circulating immunoglobulin complexes detected during the active phase of the disease disappeared during induction of remissions of active pulmonary and renal disease by immunosuppressive agents. Elevated antiglobulin activity, urinary immunoglobulin L-chain concentration and evidence of activated coagulation mechanisms were also present during active disease, and returned toward normal with treatment. Studies showed that the serum… CONTINUE READING