Circulating immunoglobulin-bound transforming growth factor beta at a late tumour-bearing stage impairs antigen-specific responses of CD4+ T cells.

Abstract

In order to elucidate the mechanisms by which tumour-specific CD4+ T-cell responses are impaired during tumour development, an attempt was made to identify factors which impair CD4+ T-cell responses at a late tumour-bearing stage. Plasma from mice bearing B16 melanoma for 30 days (plasma d30) showed a more profound immunosuppressive effect on the in vitro… (More)
DOI: 10.1046/j.1365-2249.2002.01806.x

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@article{Harada2002CirculatingIT, title={Circulating immunoglobulin-bound transforming growth factor beta at a late tumour-bearing stage impairs antigen-specific responses of CD4+ T cells.}, author={Mamoru Harada and Katsunori Tatsugami and Mika Nomoto and Kazuo Nomoto}, journal={Clinical and experimental immunology}, year={2002}, volume={128 2}, pages={204-12} }