Circulating human antibody-secreting cells during vaccinations and respiratory viral infections are characterized by high specificity and lack of bystander effect.

@article{Lee2011CirculatingHA,
  title={Circulating human antibody-secreting cells during vaccinations and respiratory viral infections are characterized by high specificity and lack of bystander effect.},
  author={F. Eun-Hyung Lee and Jessica L. Halliley and Edward E. Walsh and Andrew P. Moscatiello and Brittany L. Kmush and Ann R Falsey and Troy D. Randall and Denise A. Kaminiski and Richard K. Miller and Ig{\~n}acio Sanz},
  journal={Journal of immunology},
  year={2011},
  volume={186 9},
  pages={5514-21}
}
Surges of serum Abs after immunization and infection are highly specific for the offending Ag, and recent studies demonstrate that vaccines induce transient increases in circulating Ab-secreting cells (ASCs). These ASCs are highly enriched but not universally specific for the immunizing Ag, suggesting that a fraction of these ASCs could arise from polyclonal bystander stimulation of preexisting memory cells to unrelated Ags. This model is proposed to explain maintenance of long-lived… CONTINUE READING
24 Extracted Citations
34 Extracted References
Similar Papers

Citing Papers

Publications influenced by this paper.
Showing 1-10 of 24 extracted citations

Referenced Papers

Publications referenced by this paper.
Showing 1-10 of 34 references

Similar Papers

Loading similar papers…