Circulating ghrelin levels are decreased in human obesity.

  title={Circulating ghrelin levels are decreased in human obesity.},
  author={Matthias Tschoep and Christian Weyer and Pietro Antonio Tataranni and Viswanath Devanarayan and Eric Ravussin and Mark L. Heiman},
  volume={50 4},
Ghrelin is a novel endogenous natural ligand for the growth hormone (GH) secretagogue receptor that has recently been isolated from the rat stomach. Ghrelin administration stimulates GH secretion but also causes weight gain by increasing food intake and reducing fat utilization in rodents. To investigate the possible involvement of ghrelin in the pathogenesis of human obesity, we measured body composition (by dual X-ray absorption) as well as fasting plasma ghrelin concentrations… CONTINUE READING
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