Circulating free DNA in the progression of liver damage to hepatocellular carcinoma.

@article{Piciocchi2013CirculatingFD,
  title={Circulating free DNA in the progression of liver damage to hepatocellular carcinoma.},
  author={Marika Piciocchi and Romilda Cardin and Alessandro Vitale and Veronica Vanin and Anna Laura Giacomin and Caterina Pozzan and Gemma Maddalo and Umberto Cillo and Maria Guido and Fabio Farinati},
  journal={Hepatology international},
  year={2013},
  volume={7 4},
  pages={
          1050-7
        }
}
PURPOSE Circulating free DNA (cfDNA) is an extracellular DNA released in the blood by tumor apoptotic/necrotic cells. cfDNA determination has been proposed as a non-invasive and sensitive marker in the diagnosis of cancer. Our aim was to validate the quantification of cfDNA as a diagnostic and prognostic tool in hepatocellular carcinoma (HCC). METHODS cfDNA was quantified by real-time PCR amplification of the hTERT gene in 142 plasma samples obtained from 66 patients with HCC, 35 with… CONTINUE READING
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