Circulating free DNA in plasma or serum as biomarker of carcinogenesis: practical aspects and biological significance.

@article{Gormally2007CirculatingFD,
  title={Circulating free DNA in plasma or serum as biomarker of carcinogenesis: practical aspects and biological significance.},
  author={Emmanuelle Gormally and E. Caboux and Paolo Vineis and Pierre Hainaut},
  journal={Mutation research},
  year={2007},
  volume={635 2-3},
  pages={105-17}
}
The presence of small amounts of tumor DNA in cell free DNA (CFDNA) circulating in the plasma or serum of cancer patients was first demonstrated 30 years ago. Since then, overall plasma DNA concentration in cancer patients and genetic or epigenetic alterations specific to tumor DNA have been investigated in patients diagnosed with different types of cancer. The proportion of patients with altered CFDNA varies with the pathology and the nature of the marker. However, several studies have… CONTINUE READING