Circulating fibrocytes traffic to the lungs in response to CXCL12 and mediate fibrosis.

@article{Phillips2004CirculatingFT,
  title={Circulating fibrocytes traffic to the lungs in response to CXCL12 and mediate fibrosis.},
  author={Roderick J. Phillips and Marie D. Burdick and Kurt M Hong and Marin Lutz and Lynne A. Murray and Ying Ying Xue and John A Belperio and Michael P. Keane and Robert Strieter},
  journal={The Journal of clinical investigation},
  year={2004},
  volume={114 3},
  pages={
          438-46
        }
}
Previous reports have identified a circulating pool of CD45(+) collagen I(+) CXCR4(+) (CD45(+)Col I(+)CXCR4(+)) cells, termed fibrocytes, that traffic to areas of fibrosis. No studies have demonstrated that these cells actually contribute to fibrosis, however. Pulmonary fibrosis was originally thought to be mediated solely by resident lung fibroblasts. Here we show that a population of human CD45(+)Col I(+)CXCR4(+) circulating fibrocytes migrates in response to CXCL12 and traffics to the lungs… 
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