Circulating fetal DNA: its origin and diagnostic potential-a review.

@article{Bianchi2004CirculatingFD,
  title={Circulating fetal DNA: its origin and diagnostic potential-a review.},
  author={Diana W. Bianchi},
  journal={Placenta},
  year={2004},
  volume={25 Suppl A},
  pages={
          S93-S101
        }
}
  • D. Bianchi
  • Published 1 April 2004
  • Medicine, Biology
  • Placenta
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The origin and clearance of fetal genetic material in the maternal circulation, its presence in urine, circulating RNA, prediction of D blood group, fetal sex and new single gene disorders are discussed.
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Fruitful research efforts resulted in the clinical implementation of a number of non-invasive prenatal tests based on maternal plasma DNA analysis and included tests for fetal sex assessment, fetal rhesus D blood group genotyping and fetal chromosomal aneuploidy detection.
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If once fetal DNA should be used as a marker for determining preeclampsia at early stage, it is necessary to reduce variations via standardized protocols for the quantification of cell-free fetal DNA as well as its reporting in the publications.
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  • J. MaronD. Bianchi
  • Biology, Medicine
    American journal of medical genetics. Part C, Seminars in medical genetics
  • 2007
TLDR
Prenatal diagnosis is poised to evolve from detection of aneuploidy to detection of deviation from normal development, which should provide novel opportunities for fetal treatment.
Quantification of Cell-Free DNA in Normal and Complicated Pregnancies: Overcoming Biological and Technical Issues
The characterization of cell-free DNA (cfDNA) originating from placental trophoblast in maternal plasma provides a powerful tool for non-invasive diagnosis of fetal and obstetrical complications. Due
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